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Osmometer types

Freezing Point Osmometry (FPO)

FPO provides rapid and inexpensive results with the industry preferred freezing point method. Requires small sample size and ideally suited for most biological and aqueous applications.

•Performs rapid and inexpensive measurements
•Simple and reliable performance Industry preferred FP method
•Small sample size (μL)
•Ideal for dilute biological and aqueous solutions
•Samples must be of low viscosity
•May not be suitable for high molality or colloidal solutions

Vapor Pressure Osmometry (VPO)

VPO provides fast an inexpensive measurements requiring a small sample size, although not as fast or reliable as FPO. Volatile solutes are not amenable to VPO limiting its utility in many applications

•Performs rapid and inexpensive measurements
•Small sample size (μL)
•Ideal for dilute biological and aqueous solutions
•Less accurate than FPO
•Cannot be used for volatile solutes like alcohols or other organic solvents
•Not ideally for high molality or colloidal solutions

Membrane Osmometry (MO)

MO provides a direct measurement of osmolality and is suitable for high molality and colloidal samples. Long analysis time and requires a large sample volume. Not applicable for small molecule applications.

•Provides potentially unlimited direct measurement of osmotic pressure and solution osmolality
•Good for colloidal solutions
•No limitation on sample concentration
•Can determine MW of macromolecules
•Time consuming and difficult to operate
•Requires large sample volume
•Not applicable for small molecules and aggressive solvents due to membrane porosity and compatibility
•Irreproducible results due to clogging of membrane pores